Pre-prints:
bioRxiv (2025)
Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes
Burton J, Siller-Farfan JA, Andre V, Jenkins E, Barton MI, Bustamante Eguiguren S, Cabezas-Caballero J, Davis SJ, Weikl TR, van der Merwe PA, Dushek O
bioRxiv (2025)
Selected publications:
The molecular reach of antibodies crucially underpins their viral neutralisation capacity
Huhn A, Nissley D, Wilson DB, Kutuzov M, Donat R, Tan TK, Zhang Y, Barton MI, Liu C, Dejnirattisai W, Supasa P, Mongkolsapaya J, Townsend A, James W, Screaton G, van der Merwe PA, Deane CM, Isaacson SA, Dushek O
Nature Communications (2025)
Using CombiCells, a platform enabling titration and combinatorial display of cell surface ligands, to study T cell antigen sensitivity by TCRs, CARs, and BiTEs
Patel A, Andre V, Eguiguren SB, Barton MI, Denham EM, Pettmann J, Morch AM, Kutuzov MA, Siller-Farfan JA, Dustin ML, van der Merwe PA, Dushek O
The EMBO Journal (2024)
Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors
Burton J, Siller-Farfan JA, Pettmann J, Salzer B, Kutuzov M, van der Merwe PA, Dushek O
PNAS (2023)
Mechanical forces impair antigen discrimination by reducing differences in T cell receptor off-rates (see associated News & Views)
Pettmann J, Awada L, Bartosz R, Huhn A, Faour S, Kutuzov M, Limozin L, Weikl TR, van der Merwe PA, Robert P, Dushek O
The EMBO Journal (2023)
The discriminatory power of the T cell receptor (see associated Press Release)
*Pettmann J, *Huhn A, *Abu Shah E, Kutuzov MA, Wilson DB, Dustin ML, Davis SJ, van der Merwe PA, Dushek O
eLife (2021)
Molecular mechanisms of T cell sensitivity to antigen
Farfán JAS, Dushek O
Immunological Reviews (2018)
Architecture of a minimal signalling pathway explains the T cell response to a 1,000,000-fold variation in antigen affinity and dose
Lever M, Lim HS, Kruger P, Nguyen J, Trendel N, Abu-Shah E, Maini PK, van der Merwe PA, Dushek O
PNAS (2016)
Phenotypic models of T cell activation
Lever M, Maini PK, van der Merwe PA, Dushek O
Nature Reviews Immunology (2014)
Non-catalytic tyrosine-phosphorylated receptors.
Dushek O, Goyette J, van der Merwe PA
Immunological Reviews (2012)
Mechanisms for T cell receptor triggering.
van der Merwe PA, Dushek O
Nature Reviews Immunology (2011)
A complete list can be found on Google Scholar / PubMed.
