Publications

Pre-prints:

Regulation of temporal cytokine production by co-stimulation receptors in TCR-T cells is lost in CAR-T cells

Patel A, Kutuzov MA, Dustin ML, van der Merwe PA, Dushek O

Immunotherapy Advances (2024) In Press (available on bioRxiv)

Analysis of emergent bivalent antibody binding identifies the molecular reach as a critical determinant of SARS-CoV-2 neutralisation potency

Huhn A, Nissley D, Wilson DB, Kutuzov M, Donat R, Tan TK, Zhang Y, Barton MI, Liu C, Dejnirattisai W, Supasa P, Mongkolsapaya J, Townsend A, James W, Screaton G, van der Merwe PA, Deane CM, Isaacson SA, Dushek O

bioRxiv (2023)

Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering

Li F, Roy S, Niculcea J, Gould K, Adams EJ, van der Merwe PA, Choudrui K

bioRxiv (2023)

Ligand requirements for immunoreceptor triggering
Barton MI, Paterson RL, Denham EM, Goyette J, van der Merwe PA

bioRxiv (2023)

Selected publications:

Using CombiCells, a platform enabling titration and combinatorial display of cell surface ligands, to study T cell antigen sensitivity by TCRs, CARs, and BiTEs
Patel A, Andre V, Eguiguren SB, Barton MI, Denham EM, Pettmann J, Morch AM, Kutuzov MA, Siller-Farfan JA, Dustin ML, van der Merwe PA, Dushek O
The EMBO Journal (2024)

Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors
Burton J, Siller-Farfan JA, Pettmann J, Salzer B, Kutuzov M, van der Merwe PA, Dushek O
PNAS (2023)

Mechanical forces impair antigen discrimination by reducing differences in T cell receptor off-rates (see associated News & Views)
Pettmann J, Awada L, Bartosz R, Huhn A, Faour S, Kutuzov M, Limozin L, Weikl TR, van der Merwe PA, Robert P, Dushek O
The EMBO Journal (2023)

The discriminatory power of the T cell receptor (see associated Press Release)
*Pettmann J, *Huhn A, *Abu Shah E, Kutuzov MA, Wilson DB, Dustin ML, Davis SJ, van der Merwe PA, Dushek O
eLife (2021)

Molecular mechanisms of T cell sensitivity to antigen
Farfán JAS, Dushek O
Immunological Reviews (2018)

Architecture of a minimal signalling pathway explains the T cell response to a 1,000,000-fold variation in antigen affinity and dose
Lever M, Lim HS, Kruger P, Nguyen J, Trendel N, Abu-Shah E, Maini PK, van der Merwe PA, Dushek O
PNAS (2016)

Phenotypic models of T cell activation
Lever M, Maini PK, van der Merwe PA, Dushek O
Nature Reviews Immunology (2014)

An induced rebinding model of antigen discrimination
Dushek O, van der Merwe PA
Trends in Immunology (2014)

Non-catalytic tyrosine-phosphorylated receptors.
Dushek O, Goyette J, van der Merwe PA
Immunological Reviews (2012)

Mechanisms for T cell receptor triggering.
van der Merwe PA, Dushek O
Nature Reviews Immunology (2011)

A complete list can be found on Google Scholar / PubMed.